The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. Before you make any Week 6 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model. However, the Buccaneers will be well rested and are likely to have a chip on their shoulders as home NFL underdogs with a winning record. The Lions are one of three teams that are 4-1 against the spread this season and could be a popular option for NFL bets. It's an unexpected marquee matchup in the NFC and the latest Week 6 NFL odds list the Lions as three-point favorites on the road. In Week 6, they'll visit the Tampa Bay Buccaneers, who have also come out of the gates well at 3-1 and have the added benefit of coming off a bye week. The Detroit Lions have been one of the feel-good stories in the NFL this season and a 4-1 start has led to a two-game lead in the NFC North standings.